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Near-Infrared Light-Controlled Dynamic Hydrogel for Modulating Mechanosensitive Ion Channels in 3-Dimensional

Xiaoning Liu1, Zimeng Zhang2, Zhanshuo Cao3

  • 1School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300401, China.

Biomaterials Research
|April 10, 2025
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Summary

Researchers created a novel fibrous hydrogel that uses near-infrared light to dynamically control cell mechanics, modulating mechanosensitive ion channels and enhancing cell function.

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Area of Science:

  • Biomaterials Science
  • Cellular Mechanobiology
  • Nanotechnology

Background:

  • The extracellular matrix (ECM) mechanically influences cell behavior through mechanotransduction.
  • Mechanosensitive ion channels convert mechanical stimuli into cellular signals, regulating vital functions.
  • Controlling the mechanical microenvironment is key to understanding and manipulating cellular responses.

Purpose of the Study:

  • To develop a near-infrared (NIR) light-responsive hydrogel for dynamic control of cellular mechanotransduction.
  • To investigate the modulation of mechanosensitive ion channels (Piezo1, TRPV4) using this novel material.
  • To assess the impact of dynamic mechanical modulation on endothelial cell angiogenic potential.

Main Methods:

  • Fabrication of a fibrous hydrogel composite (PIC/OEG-NPs) from polyisocyanide (PIC) and oligo-ethylene glycol (OEG)-grafted nanoparticles (OEG-NPs).
  • Utilized NIR light to induce thermoresponsive changes in the hydrogel's mechanical properties (increased tension, tighter network).
  • Applied the dynamic hydrogel system to modulate mechanosensitive ion channels in HEK-293T and human umbilical vein endothelial cells (HUVECs).

Main Results:

  • The PIC/OEG-NPs hydrogel demonstrated reversible, NIR-controlled changes in mechanical properties.
  • NIR stimulation effectively modulated the activity of Piezo1 and TRPV4 mechanosensitive ion channels.
  • Enhanced angiogenic potential was observed in HUVECs cultured within the dynamic hydrogel system.

Conclusions:

  • A novel NIR-light-controlled fibrous hydrogel platform enables dynamic, 3D in situ modulation of mechanosensitive ion channels.
  • This technology offers a versatile tool for studying mechanobiology and developing new therapeutic strategies.
  • The findings highlight the potential of biomaterial-based mechanical control for regenerative medicine applications.