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Updated: May 15, 2025

Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Advances in engineered bacteria vaccines for enhancing anti-cancer immunity
Wu Liu1, Wenjing Chen2, Yujie Cai2
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China.
Abstract:
Advances in synthetic biology have enabled the development of tumor-targeted live bacterial therapeutics. In a recent study published in Nature, Redenti et al. engineered Escherichia coli Nissle 1917(EcNcΔlon/ΔompT/LLO+ nAg), which exploits the advantages of living medicines to deliver arrays of tumor-specific neoantigenic epitope in optimal environments, thereby providing a novel strategy for developing effective and durable cancer immunotherapies.
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