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Updated: May 15, 2025

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
Published on: August 12, 2019
A Tricyclo[4.3.1]decane Diterpenoid Skeleton from Croton laui: Isolation and 1H NMR-Based Metabolomic Profiling
Qing Li1, Chen-Sen Xu1, Hao-Lin Yu1
1Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.
Abstract:
Lauicyclone A (1), a new skeletal diterpenoid characterized by an unprecedented carbon skeleton, represents the first reported natural product featuring a complex tricyclo[4.3.1]decane framework. Along with Lauicyclones B-E (2-5), all five compounds were isolated from Croton laui. Comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray diffractions were used to identify their structures. The antitumor mechanism of compound 1 was investigated using 1H NMR-based metabolomics.
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