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Updated: May 15, 2025

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
Latest findings challenge behavioural approaches to the management of antipsychotic-induced weight gain
Steve Kisely1,2,3,4,5, Dan Siskind1,2, Helene Speyer6
1School of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Abstract:
Obesity is a major health problem among people with severe mental illness, linked to increased risk of chronic diseases and reduced life expectancy. This is attributable to a combination of factors, including lifestyle, social circumstances, medication side-effects and the illness itself. Second-generation antipsychotics are particularly associated with weight gain, affecting treatment adherence, symptoms and quality of life.
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