Related Experiment Video
Updated: May 15, 2025

Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
Updates in perioperative hemostasis in the pediatric surgical patient
Michael Richard Greenberg1, Edmund Jooste, Natalia Diaz-Rodriguez
1Division of Pediatric Anesthesiology, Duke University, Durham, North Carolina, USA.
Insights
Pediatric patient blood management (PBM) programs are gaining traction, focusing on anemia treatment and restrictive transfusion thresholds. Evidence supports reducing allogeneic blood products in pediatric surgery, though more research is needed.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Hematology
Background:
- Pediatric perioperative bleeding and hemostasis management present unique challenges.
- Patient blood management (PBM) programs are crucial for optimizing outcomes.
Purpose of the Study:
- To review recent updates in pediatric perioperative bleeding and hemostasis management.
- To highlight advancements in patient blood management strategies for pediatric surgical patients.
Main Methods:
- Literature review of recent evidence on pediatric PBM.
- Analysis of studies on restrictive transfusion thresholds and allogeneic blood product reduction.
- Evaluation of viscoelastic testing and whole blood use in pediatric populations.
Main Results:
- Growing evidence supports restrictive transfusion thresholds and reduced allogeneic blood use in children.
- Pediatric PBM programs show promise in treating anemia and optimizing coagulation.
- Viscoelastic testing and whole blood show efficacy in pediatric settings.
Conclusions:
- Patient blood management components, including anemia treatment and restrictive transfusion, are increasingly adopted in pediatric care.
- Further evidence is required to guide anesthesiologists in pediatric hemostasis management.
- Optimizing coagulation and tolerating physiologic anemia are key PBM strategies.
Purpose Of Review:
Maintaining hemostasis in pediatric patients undergoing major surgery presents unique challenges for the anesthesiologist. This review presents the most recent updates on pediatric perioperative bleeding and hemostasis management.
Recent Findings:
Patient blood management (PBM) programs remain scarcely implemented, but recent evidence for restrictive transfusion thresholds and reduction in allogeneic blood products in the pediatric population is growing. Notable updates include support for pediatric PBM programs, restrictive transfusion thresholds, increased use of viscoelastic testing, safety and efficacy of whole blood, and management of coagulopathy in trauma.
Summary:
PBM programs and their key components have gained traction in the pediatric population in recent years: treating preoperative anemia, optimizing coagulation, and tolerating physiologic anemia through restrictive transfusion thresholds. Further evidence in the pediatric population is needed to guide the anesthesiologist.
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

