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Related Experiment Video

Updated: May 15, 2025

Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy

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Remimazolam in neurosurgery.

Milena Stojanovic¹, Radmilo Jankovic^1,2

¹Clinic for Anesthesia and Intensive Therapy, University Clinical Center Nis.

Current Opinion in Anaesthesiology

|April 10, 2025

Summary

This summary is machine-generated.

Remimazolam, a new ultrashort-acting anesthetic, offers predictable onset and rapid recovery. It shows promise for neurosurgery, potentially improving hemodynamic stability and patient arousal.

Keywords:

benzodiazepine general anesthesia neurosurgery remimazolam sedation

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Area of Science:

Anesthesiology
Pharmacology
Neurosurgery

Background:

Remimazolam is a novel intravenous anesthetic agent introduced in 2020.
It is an ultrashort-acting benzodiazepine with unique pharmacokinetic properties, metabolized by tissue esterases.
Its use is currently approved for procedural sedation and general anesthesia in select countries.

Purpose of the Study:

To review the literature and evidence regarding the use of remimazolam in neurosurgical procedures.
To evaluate the safety and efficacy of remimazolam for anesthesia and sedation in neurosurgery.

Main Methods:

Literature search of existing studies and evidence on remimazolam.
Analysis of pharmacokinetic properties, clinical effects, and safety profile.

Main Results:

Remimazolam offers predictable onset, short duration, and rapid recovery.
It has a lower risk of respiratory and cardiovascular depression compared to other agents.
Studies suggest it may improve hemodynamic stability during cerebral aneurysm coiling and does not alter cerebral metabolism, blood flow, or volume.
Its rapid arousal profile makes it suitable for awake craniotomy.

Conclusions:

Remimazolam presents desirable properties including a reduced risk of prolonged sedation and a reliable safety margin.
It is expected to enhance the safety of sedation and general anesthesia in neurosurgical settings.
Further research and clinical adoption are anticipated.