Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats

Area of Science:

• Endocrinology
• Pharmacology
• Toxicology

Background:

• Hyperthyroidism affects 2.5% of adults globally, increasing risks of osteoporosis, heart disease, and mortality.
• Thyroxine-induced hyperthyroidism in rat models is a common experimental approach.

Purpose of the Study:

• To investigate the preventive and therapeutic potential of Ovothiol A in a rat model of hyperthyroidism.
• To assess Ovothiol A's impact on biochemical markers and tissue health.

Main Methods:

• Rats were divided into protective and curative groups, with subgroups for control, hyperthyroidism (HT), and Ovothiol-A treatment.
• Hyperthyroidism was induced using oral thyroxine administration (600 mg/kg).
• Ovothiol-A was administered at 250 mg/kg to assess its effects.

Main Results:

• Ovothiol-A increased body weight, T3, T4, liver enzymes, and antioxidant markers (glutathione, catalase, GST).
• It decreased TSH, organ weight index, lipid peroxidation (MDA), and nitric oxide.
• Histopathology showed improved thyroid and liver tissues with reduced collagen deposition.

Conclusions:

• Ovothiol A exhibits significant protective and therapeutic effects against induced hyperthyroidism in rats.
• Its antithyroid activity is linked to antioxidant system stimulation, reduced inflammation, and normalization of thyroid hormone levels.