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Updated: May 15, 2025
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats
Rahma Gaber1, Ayman Saber Mohamed1, Ahmed Abdel Aziz Baiomy1
1Zoology Department, Faculty of Science; Cairo University, Giza, 12613, Egypt.
Introduction:
2.5% of adults worldwide suffer from hyperthyroidism, which is associated with osteoporosis, heart disease, and increased mortality.
Aim:
The current study evaluates the protective and therapeutic effect of Ovothiol A on Thyroxineinduced hyperthyroidism in rats.
Methods:
Experimental animals were split into two categories: protective and curative. Each group was further separated into three subgroups (6 per group): control, hyperthyroidism (HT), and Ovothiol-A (250 mg/kg). Thyroxine hormone (600 mg/kg) is administered orally to rats to induce HT.
Results:
Ovothiol-A supplementation resulted in significant decreases in organ weight index, T3, T3,T4, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, malondialdehyde, nitric oxide levels, and tumour necrosis factor-alpha while increasing in body weight, TSH, glutathione reduced, catalase, and glutathione-S-transferase levels. Histopathological investigation revealed significant thyroid and liver tissue improvements, significantly reducing collagen deposition.
Conclusion:
Ovothiol-A exhibited protective and therapeutic effects against hyperthyroidism in rats. Ovothiol-A exhibits antithyroid activity by stimulating the antioxidant system, reducing inflammation, and restoring thyroid hormone levels.
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