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Updated: May 15, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Sustainable synthesis of quinolines and pyrroles enabled by chromium-catalyzed acceptorless dehydrogenative coupling
Wantong Yue1, Qing Chen1, Chuanqi Liu1
1Department of Chemistry, College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, Shandong, 266580, China. zpech@upc.edu.cn.
Abstract:
A straightforward and atom-economical method for the synthesis of quinolines and pyrroles has been reported. Using Earth-abundant, commercially available CrCl2 salt as a catalyst and the inexpensive, bench-stable 6,6'-dimethyl-2,2'-dipyridyl as a ligand, this chromium-catalyzed acceptorless dehydrogenative coupling provides important heterocycles, quinolines and pyrroles, in synthetically useful yields with good functional group tolerance, releasing water and hydrogen gas as by-products. Notably, the described protocol was also found to be applicable to the sustainable synthesis of highly substituted fused polycyclic quinolines and pyrroles. Moreover, the synthetic value of this operationally simple protocol was demonstrated by gram-scale synthesis of quinolines.
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