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Alstoscholarisine M, a 6,7-seco-vallesamine monoterpenoid indole alkaloid with antimicrobial activity from Alstonia
Hao-Fei Yu1,2,3, Lan-Chun Zhang3, Khalid-Hassan Mohamed3
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. xdluo@mail.kib.ac.cn.
Abstract:
Alstoscholarisine M is a 6,7-seco-vallesamine monoterpenoid indole alkaloid with a rare methylcarbamate fragment, isolated from the leaves of Alstonia scholaris. Extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction elucidated its structure. The fascinating compound exhibited potential antifungal activity against Trichophyton rubrum, and its activity was roughly comparable to the first-line antifungal drug griseofulvin and significantly more effective than berberine, an important antimicrobial drug originating from plants.
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