Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment

Area of Science:

• Oncology
• Immunology
• Cell and Gene Therapy

Background:

• Immunotherapy has advanced cancer treatment by targeting the immunosuppressive tumor microenvironment.
• Intratumoral heterogeneity and immune evasion necessitate novel therapeutic strategies beyond immune checkpoint inhibitors.

Purpose of the Study:

• To review the classification and application of cell and gene therapy (CGT) for solid tumors.
• To explore CGT's mechanisms in modulating the tumor immune microenvironment and systemic immunity.
• To summarize current challenges and clinical strategies in CGT for cancer treatment.

Main Methods:

• Review of existing literature on cell and gene therapy in oncology.
• Analysis of cellular and molecular mechanisms by which CGT interacts with the tumor immune microenvironment.
• Synthesis of clinical insights and research findings.

Main Results:

• CGT demonstrates flexibility and compatibility in treating solid tumors.
• CGT effectively targets cancer cell and tumor immune microenvironment interactions.
• CGT influences both local tumor immunity and systemic immune responses.

Conclusions:

• Cell and gene therapy represents a significant advancement in cancer immunotherapy.
• CGT shifts the treatment paradigm from targeting tumors to restoring cancer-immune balance.
• Bridging research and clinical practice is crucial for advancing CGT in cancer care.