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[New developments in the prevention and management of RSV in 2025]

Thomas Brahier1, Pierre Alex Crisinel2, Oriol Manuel1

  • 1Service des maladies infectieuses, Centre hospitalier universitaire vaudois, 1011 Lausanne.

Revue Medicale Suisse
|April 10, 2025
PubMed

Insights

Respiratory syncytial virus (RSV) causes severe illness in vulnerable groups. New vaccines and antibody treatments offer promising prevention strategies to reduce RSV

Area of Science:

  • Virology
  • Immunology
  • Public Health

Context:

  • Respiratory syncytial virus (RSV) is a significant pathogen causing respiratory infections.
  • RSV infections can be severe in newborns, the elderly with comorbidities, and immunocompromised individuals.
  • In pediatrics, RSV is a leading cause of bronchiolitis and pneumonia, resulting in numerous hospitalizations.

Purpose:

  • To highlight the impact of RSV on vulnerable populations.
  • To discuss advancements in RSV prevention.
  • To project the future reduction in RSV burden.

Summary:

  • RSV infections pose a considerable health risk, particularly to infants and the elderly.
  • The introduction of vaccines like Arexvy and Abrysvo, and the infant antibody nirsevimab, marks a significant advancement in prevention.
  • These new preventive measures are anticipated to substantially decrease the overall burden of RSV.

Impact:

  • Reduced hospitalizations and morbidity associated with RSV in pediatric and elderly populations.
  • Improved public health outcomes through widespread implementation of novel preventive strategies.
  • Potential for significant healthcare cost savings due to decreased RSV-related medical interventions.

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