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Fisetin: hormesis accounts for many of its chemoprotective effects

Edward J Calabrese1, Peter Pressman2, A Wallace Hayes3

  • 1Department of Environmental Health, School of Public Health and Health Sciences, University of Massachusetts, Morrill I-N344, Amherst, MA, 01003, USA. edwardc@umass.edu.

Biogerontology
|April 10, 2025
PubMed

Insights

The flavonol fisetin shows potential for health benefits by inducing hormetic dose responses, slowing aging, and protecting the nervous system. Further research is needed to optimize its absorption and bioavailability.

Area of Science:

  • Biogerontology
  • Pharmacology
  • Toxicology

Background:

  • Hormesis, a dose-response phenomenon, is increasingly recognized for its health implications.
  • Flavonoids, like fisetin, are plant compounds with potential therapeutic properties.
  • Understanding fisetin's hormetic capacity is crucial for its application in health and disease.

Purpose of the Study:

  • To assess the capacity of fisetin to induce hormetic dose responses.
  • To evaluate fisetin's effects on aging processes and neuroprotection.
  • To identify potential therapeutic applications of fisetin.

Main Methods:

  • Integrated assessment of fisetin's dose-response effects.
  • Evaluation in cellular and in vivo animal models.
  • Analysis of effects on aging, senolysis, and neuroprotection endpoints.

Main Results:

  • Fisetin demonstrated hormetic dose responses across various endpoints.
  • It effectively slowed aging processes and acted as a senolytic agent.
  • Fisetin provided broad neuroprotection, including against methylmercury toxicity.

Conclusions:

  • Fisetin exhibits multi-system chemoprotective potential through hormesis.
  • Its senolytic and neuroprotective effects warrant further investigation.
  • Optimizing fisetin's absorption and bioavailability is essential for therapeutic enhancement.
Keywords:
AdaptogenBiphasic dose responseChemoprotectionHormesisHormetinLifespanSupplements

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