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Related Experiment Video

Updated: May 15, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Head and Neck Extramedullar Plasmacytoma.

İmdat Yüce1, Nezaket Tektaş1, Mete Gündoğ2

  • 1Department of Otorhinolaryngology, School of Medicine, Erciyes University, Kayseri, Turkey.

Ear, Nose, & Throat Journal
|April 10, 2025
PubMed
Summary

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B7-H3 (CD276) and CD47 Expression Are Associated with Immune Evasion and Survival Outcomes in Pediatric Medulloblastoma.

Diagnostics (Basel, Switzerland)·2026
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Evaluation of volume changes in masticatory muscles of nasopharyngeal cancer patients treated with radiotherapy using magnetic resonance imaging.

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Evaluation of long-term outcomes of functional suprahyoid neck dissection in patients with early-stage lower lip cancer.

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Platelet-Rich Fibrin Can Improve Septoplasty Results: A Prospective Randomised Controlled Trial.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2026
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Perioperative immunonutrition and outcomes in head and neck cancer surgery - a randomized clinical trial: Effects of perioperative immunonutrition in patients with head and neck cancer.

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Management of Giant Basal Cell Carcinoma with Atypical Location.

Journal of clinical practice and research·2025

Extramedullary plasmacytoma (EMP) in the head and neck, particularly the sinonasal region, requires careful diagnosis. Radiotherapy is a primary treatment, but surgery may be needed, and long-term follow-up is crucial due to potential transformation to multiple myeloma.

Area of Science:

  • Oncology
  • Pathology
  • Head and Neck Surgery

Background:

  • Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm.
  • Head and neck region involvement is uncommon, necessitating awareness for accurate diagnosis.

Purpose of the Study:

  • To share clinical experience with head and neck EMP.
  • To highlight diagnostic challenges and treatment outcomes for this rare entity.

Main Methods:

  • Retrospective review of 11 patients with head and neck EMP treated between 2000 and 2023.
  • Analysis of patient demographics, affected sites, histopathology, treatment modalities, and outcomes.

Main Results:

  • The sinonasal tract, larynx, and tonsils were most affected.
Keywords:
extramedullarflow cytometryhead and neckplasmacytoma

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  • Histopathology revealed mature or anaplastic plasma cells; flow cytometry aided differentiation from lymphoma.
  • Radiotherapy (RT) alone or combined with surgery was the primary treatment; 44-50 Gy RT was administered.

    • Conclusions:

    • EMP should be considered in submucosal, destructive head and neck tumors, especially in the sinonasal region.
    • Differential diagnosis from multiple myeloma is essential; flow cytometry is valuable.
    • RT is effective, but surgery may be required for sinonasal EMP; long-term surveillance is needed for MM transformation.