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Comment on The Study of NRG258: Limitations and Future Directions

Yue-Can Zeng1, Ming Xue1, Jun-Nv Xu1

  • 1Yue-Can Zeng, MD, PhD, Department of Radiation Oncology, Cancer Treatment Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; Ming Xue, MS, Department of Outpatient, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; Jun-Nv Xu, MD, PhD and Nan-Nan Ji, MD, Department of Radiation Oncology, Cancer Treatment Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, China; and Yi Wang, MD, PhD, Department of Transplant Surgery, the Second Affiliated Hospital of Hainan Medical University, Haikou, China.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 10, 2025
PubMed
Abstract

No abstract available in PubMed .

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Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
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