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Predictive factors for disseminated intravascular coagulation following colorectal perforation

  • 0Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
American Journal of Surgery +

|

April 10, 2025

|

April 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Postoperative disseminated intravascular coagulation (DIC) after colorectal perforation surgery significantly increases mortality risk. Preoperative Sequential Organ Failure Assessment (SOFA) scores can predict this complication, aiding early intervention.

Area Of Science

  • Surgical Oncology
  • Critical Care Medicine
  • Hematology

Background

  • Colorectal perforation is a critical surgical emergency.
  • Postoperative complications, including disseminated intravascular coagulation (DIC), significantly impact patient outcomes.
  • Identifying predictive factors for DIC is crucial for improving prognosis.

Purpose Of The Study

  • To investigate the association between postoperative DIC and prognosis in patients undergoing emergency colorectal perforation surgery.
  • To identify preoperative clinical factors that predict the development of postoperative DIC.

Main Methods

  • A cohort of 112 patients undergoing emergency surgery for colorectal perforation was analyzed.
  • Kaplan-Meier analysis and log-rank tests assessed 30-day survival rates.
  • Logistic regression identified preoperative predictors of postoperative DIC.

Main Results

  • The incidence of postoperative DIC was 37.5%, with an overall 30-day mortality rate of 8%.
  • Patients with postoperative DIC exhibited significantly higher 30-day mortality (16.7%) compared to those without (2.9%).
  • The preoperative Sequential Organ Failure Assessment (SOFA) score emerged as an independent predictor of postoperative DIC.

Conclusions

  • Preoperative SOFA scores are valuable for assessing the risk of postoperative DIC in colorectal perforation surgery.
  • Early identification of high-risk patients may facilitate timely intervention and potentially improve outcomes.

Keywords:

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