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Predictive factors for disseminated intravascular coagulation following colorectal perforation
Toshimichi Kobayashi1, Eiji Hidaka1, Shoma Iida1
1Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
Purpose:
To determine the relationship between postoperative disseminated intravascular coagulation (DIC) and patient prognosis after surgery for colorectal perforation and to identify preoperative predictive factors for DIC.
Methods:
We included 112 patients who underwent emergency surgery for colorectal perforation between April 2014 and September 2023. We performed a Kaplan-Meier analysis to assess 30-day postoperative survival with and without postoperative DIC, log-rank test to compare survival curves, and logistic regression analysis to identify preoperative predictive factors for postoperative DIC.
Results:
The postoperative DIC and 30-day mortality rates were 37.5 % and 8 %, respectively. The 30-day postoperative mortality rates significantly differed between patients with postoperative DIC and those without (16.7 % vs. 2.9 %). The preoperative Sequential Organ Failure Assessment (SOFA) score was an independent predictive factor for postoperative DIC.
Conclusion:
Evaluating preoperative SOFA scores may help assess postoperative DIC risk and enable early initiation of anticoagulant therapy in patients undergoing surgery for colorectal perforation.
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