Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Complement System01:27

Complement System

1.9K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
1.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

411
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

740
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
740
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

66.3K
Overview
66.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dipeptidyl peptidase 3 sets the threshold for immune activation and survival during experimental bacterial infection.

Nature communications·2026
Same author

IL1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma.

Cancer immunology research·2026
Same author

Turn CAR T against TAMs.

Cancer cell·2026
Same author

Activation of B1 B cells by F. tularensis atypical LPS depends on classical complement and C3a.

PLoS pathogens·2025
Same author

Iatrogenic mitral valve injury following aortic valve surgery-a literature review.

Indian journal of thoracic and cardiovascular surgery·2025
Same author

A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity.

Frontiers in immunology·2025

Related Experiment Video

Updated: May 15, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K

Interplay between the complement system and other immune pathways in the tumor microenvironment.

Cecilia Garlanda1, Monica Dambra2, Elena Magrini2

  • 1Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele 20072, Italy; IRCCS, Humanitas Research Hospital, Milan, Rozzano 20089, Italy.

Seminars in Immunology
|April 10, 2025
PubMed
Summary

The complement system

Keywords:
Cancer-related inflammationComplementMyeloid cellsTumor-associated MacrophagesTumor-associated neutrophils

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

231
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

7.4K

Related Experiment Videos

Last Updated: May 15, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
06:54

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

Published on: June 15, 2019

5.9K
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

231
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

7.4K

Area of Science:

  • Immunology and Cancer Biology: Investigating the dual role of the complement system in tumor progression and immune evasion.

Background:

  • The tumor microenvironment (TME) critically influences cancer growth and spread.
  • Inflammatory pathways, including the complement system, play a significant role in shaping the TME and anti-tumor immunity.

Purpose of the Study:

  • To elucidate the complex and often contradictory roles of complement activation in cancer.
  • To explore the interactions between complement, immune cells (especially myeloid cells), and tumor progression.
  • To evaluate the therapeutic potential of targeting complement pathways in cancer treatment, particularly macrophage reprogramming.

Main Methods:

  • Review of preclinical studies on complement activation in cancer-related inflammation and immunosuppression.
  • Analysis of the interactions between complement components and immune cells within the tumor microenvironment.
  • Examination of clinical trial data and outcomes related to complement-targeting therapies.

Main Results:

  • Complement activation can promote tumor growth and immune suppression, particularly via myeloid cell involvement.
  • The specific role of complement is highly context-dependent, varying with tumor type, stage, and other microenvironmental factors.
  • Preclinical data suggest complement targeting can enhance immunotherapy, but clinical trial failures highlight complexity.

Conclusions:

  • The complement system presents a complex therapeutic target in oncology due to its multifaceted roles.
  • Further research is needed to identify patient subsets who could benefit from specific complement-targeted therapies.
  • Targeting complement, especially in conjunction with macrophage reprogramming, holds promise for improving cancer treatment efficacy.