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The Effect of Positron Emission Tomography-Computed Tomography Parameters on Pathological Response in Patients with
Serhat Sekmek1, Ozkan Bayrakcı2, Mehmet Akif Karacan2
1Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, Turkey.
Introduction:
We aimed to evaluate the relationship between positron emission tomography (PET)/computed tomography (CT) parameters with pathological complete response (pCR) in patients with HER-2-positive breast cancer who received neoadjuvant treatment (NACT).
Methods:
This retrospective study included 97 patients. The primary endpoint was pCR. ROC analysis was used to find the cut-off values of PET/CT parameters.
Results:
The median age of the patients was 50.8 (24.8-77.6) years. When the factors affecting the pCR of the patients after neoadjuvant treatment were analysed, it was observed that patients with low N stage (p = 0.046), patients with high lymph node (LN) metabolic tumour volume (MTV) value (p = 0.030) and high LN total lesion glycolysis (TLG) value (p = 0.014) had more pCR in their operation pathologies after NACT. Binary logistic regression analysis showed that both low N stage (hazard ratio [HR]: 0.073, 95% confidence interval [CI]: 0.016-0.332, p = 0.001) and high LN-TLG value (HR: 0.106, 95% CI: 0.016-0.727, p = 0.022) were independent risk factors affecting pCR. LN-MTV value was not statistically significant in regression analysis (p = 0.456).
Conclusion:
As a result of this retrospective study, it was observed that the group with high LN-TLG, one of the PET/CT parameters, had more pCR.
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