Correlation between Insulin Resistance and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty

This study was performed to investigate the influence of insulin resistance (IR) on bone turnover markers in girls with idiopathic central precocious puberty (ICPP).

One hundred and sixteen ICPP girls and 91 healthy girls were enrolled in this study. The levels of total procollagen type I N-terminal propeptide (P1NP), N-terminal midfragment of osteocalcin (N-MID), β-C-terminal telopeptide of type 1 collagen (β-CTX), insulin, and other biochemical parameters were detected.

The serum P1NP and β-CTX levels were significantly different between the non-IR and IR groups and the control group (p < 0.05). Serum N-MID was not significantly different among the groups (p > 0.05). The serum P1NP level was negatively correlated with vitamin D (r = -0.162, p < 0.05) and positively correlated with homeostatic model assessment for IR (r = 0.160, p < 0.05).

The influence of ICPP on bone turnover markers may be associated with IR for girls with ICPP. Strict blood glucose control and insulin regulation appear to play an extremely important role in restoring bone metabolism status in ICPP girls.