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Predictive Value of Serum D-Dimer and Prothrombin Time for Adverse Events in Patients with Acute Myocardial
Insights
D-dimer (D-D) and prothrombin time (PT) can predict the severity of acute myocardial infarction (AMI) and adverse cardiovascular events. Higher D-D and PT levels indicate increased risk in AMI patients.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Diagnostics
Background:
- Acute myocardial infarction (AMI) poses significant risks for cardiovascular events.
- Predictive markers for AMI severity and outcomes are crucial for patient management.
Purpose of the Study:
- To evaluate the predictive value of D-dimer (D-D) and prothrombin time (PT) for AMI severity.
- To assess the role of D-D and PT in predicting adverse cardiovascular events in AMI patients.
Main Methods:
- 314 AMI patients undergoing percutaneous coronary intervention (PCI) were analyzed.
- Patients were classified into severe and non-severe groups based on Killip classification.
- Blood biochemical and coagulation tests, including D-D and PT, were performed within 2 hours of admission.
Main Results:
- Elevated D-D and PT levels were observed in the severe AMI group compared to the non-severe group (p < 0.05).
- D-D and PT demonstrated superior predictive performance over cTnT and NT-proBNP for severe AMI.
- Previous heart failure history, left ventricular ejection fraction, PT, and D-D were identified as independent risk factors for adverse cardiovascular events.
Conclusions:
- Serum D-D and PT are valuable predictors of adverse cardiovascular events in patients with AMI.
- These markers can aid in risk stratification and management of AMI patients.
Background:
This study aimed to investigate the predictive value of D-dimer (D-D) and prothrombin time for severity and adverse cardiovascular events in patients with acute myocardial infarction (AMI).
Methods:
A total of 314 patients who were diagnosed with AMI and underwent percutaneous coronary intervention (PCI) in the Department of Cardiology, Linquan People's Hospital, from January 2020 to December 2023 were selected. According to Killip classification, patients were divided into severe and non-severe AMI groups. Within 2 hours after admission, 3 mL of cubital venous blood were drawn for blood biochemical and coagulation tests. According to the patient's electrocardiogram, coronary angiography, and other tests, the diagnosis of acute myocardial infarction was confirmed.
Results:
D-D and prothrombin time (PT) in the severe group were significantly higher than those in the non-severe group, and the difference was statistically significant (p < 0.05). The number of patients with PCI of left circumflex artery, right coronary artery stent implantation, single and double stent implantation in the severe group was higher than that in the non-severe group, and the results were statistically significant (p < 0.05). The results of ROC curve showed that the area under the curve, sensitivity, and specificity of D-D and PT were significantly better than those of cardiac troponin T(cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with severe myocardial infarction (p < 0.05). In addition, the results of bivariate regression analysis showed that D-D and PT were significantly correlated with Killip classification (p < 0.05). Multivariate logistic regression analysis showed that previous history of heart failure, left ventricular ejection fraction, PT, and D-D were independent risk factors for adverse cardiovascular events in patients with AMI (p < 0.05).
Conclusions:
Serum D-D and PT have important predictive value for adverse cardiovascular events in patients with AMI.
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