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Updated: Aug 5, 2026
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
B-ALL with CD34 Negative and Surface Immunoglobulin Light Chain Restricted Expression
Background:
The morphologic features of acute lymphoblastic leukemia (ALL) overlap greatly with other blastoid-HGBL or some mature B-cell lymphomas. Blastoid morphology is currently a diagnostic challenge.
Methods And Results:
Our case presents a B-ALL with surface IgD and immunoglobulin light chain Kappa restricted expression, CD13 and CD33 were partial expressed and negative for CD34. The patient achieved morphologic remission after one cycle of treatment.
Conclusions:
In this case, the expression of immunophenotypic features does not clearly distinguish whether the B cells are in a mature or immature stage. In some situations, these lymphoblasts cells are hardly distinguishable from mature cells.
