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Obesity is associated with impaired long-term prognosis in patients undergoing coronary angiography: Results from a large-scaled single centre registry

  • 0Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany.
International Journal of Cardiology +

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April 10, 2025

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April 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Severely obese patients (BMI ≥35 kg/m²) undergoing coronary angiography face the highest risk of heart failure rehospitalization within 36 months. This finding highlights the prognostic impact of obesity in cardiovascular care.

Area Of Science

  • Cardiology
  • Public Health
  • Obesity Research

Background

  • Obesity is a global health concern and a known risk factor for coronary artery disease (CAD).
  • The prognostic implications of body mass index (BMI) in patients undergoing invasive coronary angiography (CA) remain debated.
  • This study addresses the impact of obesity on outcomes in patients referred for CA.

Purpose Of The Study

  • To investigate the prognostic value of body mass index (BMI) in a large cohort of unselected patients undergoing invasive coronary angiography (CA).
  • To assess the association between different BMI categories and adverse cardiovascular outcomes, specifically heart failure (HF) rehospitalization, acute myocardial infarction (AMI), and coronary revascularization.

Main Methods

  • A cohort of 6583 patients undergoing invasive CA between 2016 and 2022 was analyzed.
  • Patients were stratified into BMI subgroups: normal (18.5–24.9 kg/m²), overweight (25–29.9 kg/m²), and obese (≥30 kg/m²), with further stratification for severe obesity (≥35 kg/m²).
  • Outcomes assessed included rehospitalization for heart failure (HF), acute myocardial infarction (AMI), and coronary revascularization at 36 months, analyzed using multivariable adjustment.

Main Results

  • Patients with BMI 25–29.9 kg/m² exhibited the highest prevalence of CAD and 3-vessel CAD.
  • Patients with severe obesity (BMI ≥35 kg/m²) had the lowest prevalence of CAD.
  • After multivariable adjustment, a BMI ≥35 kg/m² was significantly associated with an increased risk of HF-related rehospitalization at 36 months (adjusted HR = 1.210; p = 0.038).

Conclusions

  • In patients undergoing coronary angiography, a BMI ≥35 kg/m² is linked to the highest risk of heart failure rehospitalization within 36 months.
  • These findings underscore the importance of considering severe obesity as a significant prognostic factor in patients with coronary artery disease undergoing invasive procedures.

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