Related Experiment Video
Updated: May 15, 2025
10:09
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
6.8K
Migrasomes: Critical players in intercellular nanovesicle communication
Jiayu Zhang1, Shoutao Weng2, Zaiwei Fan3
1Department of ECG, Sir Run Run Shaw Hospital, Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, China.
Cellular Signalling
|April 10, 2025
Summary
Migrasomes are novel vesicular structures involved in cell migration and intercellular communication. This review explores their formation, signaling mechanisms, and potential advantages over other extracellular vesicles.
Area of Science:
- Cell Biology
- Extracellular Vesicles
- Intercellular Signaling
Background:
- Migrasomes are vesicular structures formed during cell migration.
- They play a role in intercellular communication and signal transduction.
- Their formation is influenced by cell dynamics and the microenvironment.
Purpose of the Study:
- To provide a comprehensive overview of migrasome dynamics.
- To examine nanoscale vesicle-mediated intercellular signaling mechanisms.
- To highlight the influence of secretory factors on migrasome generation.
Main Methods:
- Literature review of migrasome formation and function.
- Analysis of migrasome characteristics and comparison with other extracellular vesicles.
- Discussion of factors influencing migrasome generation.
Main Results:
- Migrasomes are formed on tethers during cell migration.
- They facilitate intercellular communication and signal transduction.
- Microscopic secretory factors impact migrasome generation.
Conclusions:
- Migrasomes represent a distinct class of extracellular vesicles.
- They offer potential advantages for intercellular signaling.
- Further research is needed to address challenges in migrasome study.
Related Concept Videos
01:43SNAREs and Membrane Fusion
9.5K
Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
9.5K
01:26Fusion of Secretory Vesicles with the Plasma Membrane
9.7K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
9.7K
01:38Intralumenal Vesicles and Multivesicular Bodies
3.3K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.3K
01:32Cytoskeletal Coordination in Cell Migration
4.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.7K
01:10Intracellular Movement of Viruses and Bacteria
2.7K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.7K
01:35Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K