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Investigating the multifaceted role of nucleolin in cellular function and Cancer: Structure, Regulation, and
Kruthika Prakash1, Srisri Satishkartik1, Satish Ramalingam1
1Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, India.
Gene
|April 10, 2025
Summary
Nucleolin (NCL) is a key protein involved in ribosome biogenesis and cell regulation. This review explores NCL
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Nucleolin (NCL) is a conserved phosphoprotein found in various cellular compartments.
- NCL is crucial for ribosome biogenesis, DNA/RNA metabolism, and cell cycle regulation.
- NCL's structure features multiple domains and is influenced by post-translational modifications.
Purpose of the Study:
- To provide an in-depth overview of Nucleolin's structure, functions, and modifications.
- To focus on NCL's role in cancer biology.
- To discuss the therapeutic implications of targeting NCL.
Main Methods:
- Literature review of Nucleolin's structure and function.
- Analysis of NCL's involvement in cellular processes.
- Exploration of NCL's role in cancer pathology and therapeutic strategies.
Main Results:
- NCL is essential for cell viability and plays roles beyond ribosome synthesis.
- NCL contributes to tumor growth, metastasis, and drug resistance in cancer.
- Cell surface NCL acts as a co-receptor, facilitating oncogenic signaling.
Conclusions:
- NCL's multifaceted roles make it a significant factor in cancer development.
- NCL's regulation of non-coding RNAs and mRNA stabilization are critical in oncogenesis.
- Targeting NCL presents a promising therapeutic avenue for cancer treatment.
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