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Related Experiment Video

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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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STING-activable immunomodulatory bio-glue for multiple postsurgical management.

Mengzi Hu1, Yaqiong Wang2, Xue-Bo Yin1

  • 1Institute for Frontier Medical Technology, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 10, 2025
PubMed
Summary

This study presents a novel bio-glue for tumor surgery, combining hemostasis, wound healing, and anti-tumor effects. The BMGY bio-glue ablates residual tumor cells and enhances anti-tumor immunity, offering significant postsurgical management potential.

Keywords:
BSA-genipin bio-glueImmunotherapyManganese dioxidePhotothermal therapySTING activation

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Immunotherapy

Background:

  • Adhesives for tumor surgery need anti-tumor therapeutic effects.
  • Current surgical glues lack integrated therapeutic functionalities.

Purpose of the Study:

  • To develop a multifunctional bio-glue (BMGY) for tumor surgery.
  • To achieve hemostasis, wound bonding, tumor cell ablation, and anti-tumor immunity.

Main Methods:

  • Integration of bovine serum albumin (BSA)-MnO2, genipin (GP), and Ca-Y zeolite into a bio-glue.
  • Utilizing laser irradiation for photothermal suture and tumor cell ablation.
  • Investigating the activation of the cGAS-STING pathway by released Mn ions.

Main Results:

  • BMGY bio-glue demonstrated hemostasis and wound adherence within nine days.
  • Photothermal suture effectively ablated residual tumor cells and produced antigen fragments.
  • BMGY treatment significantly increased p-TBK1 and interferon-β levels, enhancing anti-tumor immunity.

Conclusions:

  • BMGY bio-glue successfully integrates hemostasis, wound bonding, tumor cell ablation, and tumor recurrence inhibition.
  • The BSA-MnO2-GP platform offers versatility for drug loading to enhance therapeutic efficacy.
  • BMGY presents a promising bio-glue paradigm with significant translational potential for postsurgical management.