Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 15, 2025

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:32

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

851

The DMC-Behavior Platform: An Open-Source Framework for Auditory-Guided Perceptual Decision-Making in Head-Fixed

Felix Jung1, Xiao Cao1, Loran Heymans1

  • 1Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden.

Eneuro
|April 10, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A prefrontal cortex map based on single-neuron activity.

Nature neuroscience·2026
Same author

A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit.

Science advances·2025
Same author

Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.

Nature communications·2024
Same author

Esr1<sup>+</sup> hypothalamic-habenula neurons shape aversive states.

Nature neuroscience·2023
Same author

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery.

Nature communications·2022
Same author

Differential modulation of parietal cortex activity by respiration and θ oscillations.

Journal of neurophysiology·2022
Same journal

Complex three-dimensional rearing environments amplify compensatory plasticity following early blindness.

eNeuro·2026
Same journal

c-Maf deletion in cortical somatostatin, but not parvalbumin, interneurons leads to absence-like epileptiform activity in mice.

eNeuro·2026
Same journal

Functional Characterization of Dopamine Projections Across Nucleus Accumbens Subregions in Reward-related, Anxiety-like and Locomotor Behaviors.

eNeuro·2026
Same journal

Translational profiling of Drd2-expressing populations reveals molecular heterogeneity of dentate gyrus mossy cells along the dorsoventral axis.

eNeuro·2026
Same journal

Movement Disorder Patients with Depression have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss.

eNeuro·2026
Same journal

Ocular speech tracking persists in blindness, but its dynamics and oculo-cerebral connectivity depend on visual status.

eNeuro·2026
See all related articles

Researchers developed an open-source platform for training mice in auditory decision-making tasks. This tool enhances standardization and reproducibility in studying neural circuits for auditory perception.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Auditory Neuroscience

Background:

  • Perceptual decision-making is crucial for animal survival and is studied in preclinical research using head-fixed mice.
  • Standardization of behavioral training, especially for auditory tasks, is often neglected in neuroscience research.
  • Existing methods for recording/manipulating neuronal activity lack synchronized behavioral training frameworks for auditory stimuli.

Purpose of the Study:

  • To introduce the DMC-Behavior Platform, an open-source, cost-efficient framework for training head-fixed mice in auditory perceptual decision-making tasks.
  • To provide a tool that integrates seamlessly with neuronal recording and manipulation technologies.
  • To enable more standardized and reproducible investigations into the neural basis of auditory-guided decision-making.
Keywords:
Raspberry Piauditoryhead-fixed behaviorsperceptual decision-makingstandardization

More Related Videos

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning
11:32

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

3.3K
A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

9.4K

Related Experiment Videos

Last Updated: May 15, 2025

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:32

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

851
A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning
11:32

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

3.3K
A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

9.4K

Main Methods:

  • Development of the open-source DMC-Behavior Platform.
  • Training head-fixed mice on auditory variants of detection, Go/NoGo, and two-alternative forced choice tasks.
  • Integration and synchronization of the platform with external devices for recording neuronal activity and behavioral variables.

Main Results:

  • Successful demonstration of the DMC-Behavior Platform's utility in training mice on auditory decision-making tasks.
  • Established seamless integration and synchronization capabilities with external electrophysiology and behavioral recording devices.
  • The platform facilitates the study of task-related and non-task-related behavioral variables alongside neuronal activity.

Conclusions:

  • The DMC-Behavior Platform offers a standardized and cost-efficient solution for auditory-guided perceptual decision-making research in mice.
  • This framework supports the investigation of neuronal underpinnings of cognitive processes by integrating behavioral training with neurophysiological recordings.
  • The platform is a valuable tool for advancing reproducible research in auditory neuroscience and decision-making circuits.