Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

5.7K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
5.7K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

4.6K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Support-Mediated Reversible Redox Dynamics of Pt and Au on CeO<sub>2</sub> at Room Temperature.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Effects of short-term warming and grazing on soil microbial communities in saline-alkaline grasslands of northern China.

Frontiers in microbiology·2026
Same author

Global mining has undermined forest conservation within and beyond protected areas.

Nature communications·2026
Same author

Prenatal detection and multimodality imaging of a retroperitoneal fetus-in-fetu in a neonate: a case description.

Quantitative imaging in medicine and surgery·2026
Same author

Defect-engineered hydrogen-terminated diamond optoelectronic synapses for UV-driven neuromorphic computing.

Journal of colloid and interface science·2026
Same author

Achieving the goldilocks zone of lung-targeted mRNA delivery with a charge-steric optimized quantum dot-lipid system for pulmonary fibrosis therapy.

Journal of controlled release : official journal of the Controlled Release Society·2026

Related Experiment Video

Updated: May 15, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.5K

Inhibition of esophageal squamous cell carcinoma progression by MIR210HG and activation of the P53 signaling pathway

Jianyu Wang1,2, Zhenhu Zhang1, Liang Song1

  • 1Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan, 250021, Shandong Province, China.

European Journal of Medical Research
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Long noncoding RNA MIR210HG is underexpressed in esophageal squamous cell carcinoma (ESCC). High MIR210HG expression improves patient survival and inhibits ESCC progression, potentially via the P53 pathway.

Keywords:
ApoptosisAutophagyEsophageal squamous cell carcinomaMIR210HGP53 signaling pathway

More Related Videos

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.0K
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.6K

Related Experiment Videos

Last Updated: May 15, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.5K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.0K
Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

18.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Esophageal squamous cell carcinoma (ESCC) is a prevalent cancer with high mortality due to limited early detection and treatment options.
  • The long noncoding RNA MIR210HG is implicated in various cancers, but its role in ESCC is not yet understood.

Purpose of the Study:

  • To investigate the role and potential therapeutic implications of MIR210HG in esophageal squamous cell carcinoma.
  • To analyze MIR210HG expression patterns and its correlation with patient survival and tumor progression in ESCC.

Main Methods:

  • Pan-cancer analysis of The Cancer Genome Atlas (TCGA) database for MIR210HG expression.
  • Functional assays (proliferation, invasion, migration, apoptosis, autophagy) in vitro and in vivo.
  • Correlation analysis with patient survival, tumor microenvironment, and immune checkpoints.
  • Gene and protein expression analysis using Western blotting and qRT-PCR.

Main Results:

  • MIR210HG expression is significantly lower in ESCC tissues compared to normal tissues.
  • High MIR210HG expression correlates with improved overall survival and better prognosis in ESCC patients.
  • MIR210HG suppresses ESCC cell proliferation, invasion, and migration in vitro and in vivo.
  • MIR210HG positively correlates with the P53 signaling pathway, influencing autophagy and apoptosis.

Conclusions:

  • MIR210HG acts as a tumor suppressor in ESCC, impacting patient immunity and prognosis.
  • MIR210HG may regulate autophagy and apoptosis through the P53 signaling pathway, offering novel therapeutic targets for ESCC.
  • These findings provide new insights into the molecular mechanisms of ESCC and potential treatment strategies.