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Related Experiment Video

Updated: May 15, 2025

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Association between IFN-γ +874T/A SNP and COVID-19 Severity.

Seyyed Amin Seyyed Rezaei1, Vahid Asgharzadeh2, Behroz Mahdavi Poor3

  • 1Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. seyyedamin1381@gmail.com.

Iranian Journal of Allergy, Asthma, and Immunology
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Genetic factors influence COVID-19 severity. The interferon-gamma (IFN-γ) +874T/A single nucleotide polymorphism (SNP) was linked to critical illness, with the AA genotype and A allele more frequent in severe COVID-19 patients.

Keywords:
COVID-19IFN‐γPolymorphismSARS-CoV-2

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Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • COVID-19 severity varies due to individual differences, with genetic factors playing a key role.
  • The interferon-gamma (IFN-γ) gene, specifically the +874T/A single nucleotide polymorphism (SNP), is implicated in immune responses and potential COVID-19 severity.
  • Understanding genetic predispositions is crucial for personalized COVID-19 management.

Purpose of the Study:

  • To investigate the association between the IFN-γ +874T/A SNP and the clinical outcomes of COVID-19 patients.
  • To determine if specific genotypes or alleles of the IFN-γ +874T/A SNP correlate with COVID-19 severity.
  • To identify genetic markers that may predict severe disease progression in COVID-19.

Main Methods:

  • Genomic DNA was extracted from leukocytes of 416 individuals (206 critically ill COVID-19 patients and 210 healthy controls) in Iran.
  • The IFN-γ +874T/A SNP was genotyped using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method.
  • Statistical analysis was performed to compare genotype and allele frequencies between patient and control groups.

Main Results:

  • The AA genotype of the IFN-γ +874T/A SNP was significantly more prevalent in critically ill COVID-19 patients compared to healthy controls.
  • Conversely, AT and TT genotypes were more common in the healthy control group.
  • The A allele was more frequent in severe COVID-19 patients, while the T allele was more frequent in healthy individuals.

Conclusions:

  • The IFN-γ +874T/A SNP is a significant genetic factor associated with COVID-19 severity.
  • This genetic variant may influence immune responses, contributing to differential disease outcomes.
  • Findings support the role of genetic predisposition in COVID-19 severity and highlight potential for personalized medicine approaches.