Perimenopausal depression: Targeting inflammation and oxidative stress (Review)
Yang Yu1, Tianyang Yu1, Kaili Liu1
1Department of Second Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.
Molecular Medicine Reports
|April 11, 2025
Summary
Perimenopausal depression, affecting many women, involves hormonal shifts leading to neuroinflammation. This review explores anti-inflammatory and anti-oxidative treatments for this condition.
Area of Science:
- Neuroscience
- Psychiatry
- Endocrinology
Background:
- Depressive disorder affects over 300 million globally, with women disproportionately impacted.
- Perimenopausal depression is increasing due to population aging, impacting women's health.
- Symptoms include depression, stress, anxiety, and endocrine issues like hypogonadism.
Purpose of the Study:
- To review the role of neuroinflammation in perimenopausal depression.
- To explore potential anti-inflammatory and anti-oxidative therapeutic mechanisms.
Main Methods:
- Literature review focusing on neuroinflammation in perimenopausal depression.
- Analysis of hormonal changes and their link to oxidative stress and neuronal damage.
Main Results:
- Hormonal fluctuations during perimenopause (estrogen, progesterone) increase depression risk.
- These changes trigger proinflammatory mediators and oxidative stress, causing neuronal damage.
- Neuroinflammation plays a key role in the pathophysiology of perimenopausal depression.
Conclusions:
- Understanding neuroinflammation is crucial for treating perimenopausal depression.
- Targeting anti-inflammatory and anti-oxidative pathways offers potential therapeutic strategies.
- Further research into these mechanisms could lead to effective clinical treatments.
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