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Updated: May 15, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

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Published on: January 21, 2020

Complex Regional Pain Syndrome: Navigating Diagnostic Complexities.

Floris V Raasveld^1,2,3, Margaux Wolff¹, Anna Luan^1,2

¹Department of Orthopaedic Surgery, Hand and Arm Center, Massachusetts General Hospital, Harvard Medical School.

The Clinical Journal of Pain

|April 11, 2025

Summary

This summary is machine-generated.

Diagnosing Complex Regional Pain Syndrome (CRPS) is challenging. This study found variability in applying diagnostic criteria and inconsistent diagnoses, suggesting a need to address underlying nerve injuries first for better CRPS assessment.

Keywords:

Budapest criteria clinical assessment complex regional pain syndrome diagnostic validity neuropathic pain

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Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Area of Science:

Neurology
Pain Medicine
Medical Diagnostics

Background:

Complex Regional Pain Syndrome (CRPS) diagnosis is difficult due to varied presentations.
Accurate and timely diagnosis is crucial for effective patient management.
Current diagnostic pathways may lead to delays and misdiagnoses.

Purpose of the Study:

To analyze the diagnostic journey of patients with suspected CRPS.
To evaluate the application and accuracy of the Budapest criteria in CRPS diagnosis.
To identify factors influencing CRPS diagnostic accuracy and referral patterns.

Main Methods:

Retrospective analysis of 53 patients diagnosed with CRPS at a tertiary care center (2020-2024).
Review of patient demographics, referral timelines, and diagnostic evaluations.
Retrospective assessment of CRPS diagnosis validity by three independent clinicians using the Budapest criteria.

Main Results:

Median time to referral for CRPS was 1.3 years.
Budapest criteria were assessed in only 26% of patients prior to specialist evaluation.
Retrospective review confirmed CRPS in 42% of cases, with 26% found not to have CRPS; inter-rater reliability was minimal to moderate (κ=0.32-0.72).

Conclusions:

Significant variability exists in applying the Budapest criteria for CRPS diagnosis.
Inconsistencies in retrospective diagnosis highlight challenges in CRPS assessment.
Prioritizing evaluation of potentially treatable peripheral nerve injuries may improve early CRPS diagnosis and management.