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Related Experiment Video

Updated: May 15, 2025

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

Tuning the Immune Cell Response through Surface Nanotopography Engineering.

Raïssa Rathar¹, David Sanchez-Fuentes², Hugo Lachuer³

¹Institut de Recherche en Infectiologie de Montpellier (IRIM) Université de Montpellier CNRS UMR 9004 Montpellier 34000 France.

|April 11, 2025

Summary

This summary is machine-generated.

Engineered nanostructured surfaces guide dendritic cell (DC) membrane shape, influencing immune surveillance. This research shows how physical cues from SiO2 pillars modulate DC actin structures and immune signaling pathways.

Keywords:

actin organization dendritic cells membrane remodeling nanoimprint lithography nanostructured surfaces sol–gel chemistry

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Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

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Published on: March 28, 2014

Area of Science:

Immunology
Biomaterials Science
Cell Biology

Background:

Dendritic cells (DCs) are crucial for immune surveillance, detecting pathogens and aberrant cells.
DC function relies on dynamic morphology changes influenced by their environment.
The actin cytoskeleton and cell membrane interface are key to DC sensing and signaling.

Purpose of the Study:

To engineer synthetic environments that manipulate dendritic cell (DC) membrane morphology.
To investigate how engineered topographical features impact DC cellular functions.
To understand the role of membrane morphology in DC immune responses.

Main Methods:

Fabrication of one-dimensional nanostructured SiO2 surfaces using soft-nanoimprint lithography.
Culturing ex vivo human DCs on engineered SiO2 surfaces.
Utilizing super-resolution microscopy and live-cell imaging to analyze DC behavior.

Main Results:

Vertical pillar topographies on SiO2 surfaces promote actin-enriched structures in DCs.
Engineered surfaces stabilize adhesive structures and influence membrane morphology.
Specific topographies regulate innate immune receptor organization and Syk/ERK signaling pathways.

Conclusions:

Engineered SiO2 surface topographies can effectively modulate ex vivo human DC responses.
Local plasma membrane nano-deformations induced by surfaces impact cellular functions.
This approach offers insights into the physical regulation of immune cell behavior.