Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990-2021)
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View abstract on PubMed
Summary
This summary is machine-generated.Global gout prevalence and incidence have significantly increased from 1990 to 2021, with rising age-standardized rates. Disparities in gout burden are worsening between high and low socioeconomic development regions, necessitating targeted public health strategies.
Area Of Science
- Epidemiology
- Public Health
- Global Health Trends
Background
- Gout, a condition caused by hyperuricemia and monosodium urate crystal deposition, presents a significant global health challenge.
- Its prevalence is rising, contributing to serious comorbidities like cardiovascular and chronic kidney diseases.
- Understanding global trends and sociodemographic disparities is vital for effective intervention strategies.
Purpose Of The Study
- To analyze global trends in gout prevalence, incidence, and disability-adjusted life years (DALYs) from 1990 to 2021.
- To investigate the impact of demographic factors and socioeconomic development on gout burden.
- To evaluate cross-national inequalities and predict future gout trends.
Main Methods
- Analysis of gout prevalence, incidence, and DALYs data from 1990-2021, stratified by age, sex, and economic development.
- Decomposition analysis to quantify demographic impacts and advanced analysis for socioeconomic correlations.
- Prediction models for future trends and cross-national inequality assessments.
Main Results
- Global gout prevalence rose from 22.3 million to 56.5 million cases between 1990 and 2021, with age-standardized rates increasing.
- Incidence and age-standardized death rates also saw significant increases, alongside a substantial rise in DALYs.
- Aging and population growth were key drivers of increased prevalence in different regions, with widening disparities observed between high- and low-SDI countries.
Conclusions
- The global burden of gout has increased, with distinct challenges in high-SDI (lifestyle factors) and low-SDI (healthcare access) regions.
- Public health strategies must address modifiable risk factors, enhance healthcare infrastructure, and consider gender- and age-specific trends.
- Addressing these disparities is crucial for mitigating the growing impact of gout worldwide.
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