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Updated: May 15, 2025

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Bicalutamide: A review.

Shayna Aulakh1, Venkataram Mysore1

  • 1Department of Dermatology, Venkat Charmalaya - Centre for PG training and Advanced Dermatology, Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India.

Journal of Cutaneous and Aesthetic Surgery
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Bicalutamide, an androgen receptor antagonist, shows promise for treating female pattern hair loss. This review details its pharmacology, uses, and safety for dermatological research.

Keywords:
AlopeciaAndrogen ReceptorAnti-androgen drugBicalutamideFemale pattern hair loss

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Area of Science:

  • Dermatology
  • Pharmacology
  • Endocrinology

Background:

  • Bicalutamide is a non-steroidal androgen receptor antagonist.
  • It exhibits anti-androgenic effects on peripheral tissues.
  • Off-label use for female pattern hair loss (FPHL) is increasing.

Purpose of the Study:

  • To review the pharmacological properties of bicalutamide.
  • To discuss its indications and contraindications in dermatological research.
  • To evaluate the safety profile of bicalutamide for FPHL treatment.

Main Methods:

  • Literature review of pharmacological data.
  • Analysis of clinical studies and case reports on bicalutamide for FPHL.
  • Assessment of safety and tolerability data.

Main Results:

  • Bicalutamide effectively antagonizes androgen receptors, reducing androgenic effects.
  • Evidence suggests potential improvement in Sinclair grading for FPHL.
  • Established indications, contraindications, and safety considerations are outlined.

Conclusions:

  • Bicalutamide presents a viable therapeutic option for FPHL.
  • Further research is warranted to establish definitive efficacy and safety.
  • Understanding its profile is crucial for responsible dermatological application.