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Updated: May 8, 2026
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Designer DNA nanocages modulate anti-oxidative and anti-inflammatory responses in tumor associated macrophages
Payal Vaswani1, Dhiraj Bhatia1
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar Palaj 382355 Gujarat India dhiraj.bhatia@iitgn.ac.in.
Abstract:
Cancer is a complex disease, with multiple treatment modalities, but no definitive cure. The tumor microenvironment contributes to the complexity of the disease by forming a niche of multiple cell types supporting each other to carry out various cellular functions. Tumor associated macrophages are one such kind of cells which support the tumor microenvironment via immunosuppression. DNA tetrahedron (TD), a widely explored DNA nanocage, has shown a lot of potential in therapeutics. However, the role of TD still remains quite unexplored in immunology. Here, we first establish the anti-oxidative and anti-inflammatory role of TD. We then proceed with using TD as a therapeutic agent in tumor associated macrophages by modulating the response of PD-L1. The findings of this work create a base for TD in biological applications such as cancer immunotherapy.
Insights
DNA tetrahedrons (TDs) show anti-oxidative and anti-inflammatory effects, offering a new approach to cancer immunotherapy by modulating tumor-associated macrophages and PD-L1 responses.
Area of Science:
- Immunology
- Nanotechnology
- Biomedical Engineering
Background:
- Cancer immunotherapy faces challenges due to the complex tumor microenvironment.
- Tumor-associated macrophages (TAMs) within the microenvironment promote tumor growth via immunosuppression.
- DNA tetrahedrons (TDs) are promising nanostructures with unexplored roles in immunology.
Purpose of the Study:
- To investigate the anti-oxidative and anti-inflammatory properties of DNA tetrahedrons (TDs).
- To explore the therapeutic potential of TDs in modulating tumor-associated macrophages (TAMs) and PD-L1 responses for cancer immunotherapy.
Main Methods:
- Established the anti-oxidative and anti-inflammatory effects of TD.
- Utilized TD as a therapeutic agent targeting TAMs.
- Assessed the modulation of PD-L1 response in the tumor microenvironment.
Main Results:
- Demonstrated significant anti-oxidative and anti-inflammatory roles for TD.
- Showcased TD's efficacy in modulating TAMs and PD-L1 expression.
- Provided evidence for TD's potential in cancer immunotherapy.
Conclusions:
- DNA tetrahedrons exhibit beneficial anti-oxidative and anti-inflammatory properties.
- TDs show promise as a therapeutic strategy for modulating the tumor microenvironment in cancer immunotherapy.
- This study lays the groundwork for further development of TDs in biological and therapeutic applications.
