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  11. Association Of Magnesium Depletion Score With Serum Anti-aging Protein Klotho In The Middle-aged And Older Populations

Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations

Zhijie Zhuang1, Shan Huang2, Yingzhu Xiong3

  • 1Department of Gastroenterology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, China.

Frontiers in Nutrition
|April 11, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Magnesium depletion, measured by the Magnesium Depletion Score (MDS), is inversely associated with serum Klotho levels in US adults. Lower magnesium status predicts lower anti-aging protein Klotho, potentially indicating accelerated aging risks.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Biochemistry

Background:

  • Magnesium deficiency and low Klotho are linked to age-related diseases.
  • The Magnesium Depletion Score (MDS) is a reliable indicator of body magnesium status.
  • The relationship between magnesium status and serum Klotho is unexplored.

Purpose of the Study:

  • To investigate the association between magnesium depletion (MDS) and serum Klotho levels in US adults.
  • To explore the role of magnesium status in predicting Klotho levels.
  • To identify potential biomarkers for aging and related diseases.

Main Methods:

  • Analysis of 11,387 US adults (aged 40-79) from NHANES (2007-2016).
  • Participants categorized into low, middle, and high MDS groups.
Keywords:
KlothoNHANEScross-sectional studymagnesium depletion score

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  • Multivariable linear regression models adjusted for confounders.

    • Main Results:

    • Serum Klotho concentrations significantly decreased with increasing MDS.
    • Higher MDS (poorer magnesium status) was associated with significantly lower serum Klotho levels.
    • Inverse association was consistent across subgroups, notably in leaner individuals, smokers, and low-income participants.

    Conclusions:

    • An inverse association exists between magnesium depletion (MDS) and serum Klotho levels in US adults.
    • MDS may help identify individuals at risk of accelerated aging.
    • Further research is needed to understand the mechanisms and implications for age-related diseases.
    nutrition