Significance of Epidermal Growth Factor Receptor (EGFR) upregulation in the prediction of the malignant transformation risk in oral potentially malignant disorders: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Epidermal Growth Factor Receptor (EGFR) upregulation is a significant predictor of malignant transformation risk in oral potentially malignant disorders (OPMD). This finding highlights EGFR as a key biomarker for OPMD progression.
Area Of Science
- Oncology
- Oral Pathology
- Biomarker Research
Background
- Oral potentially malignant disorders (OPMD) carry a risk of malignant transformation.
- Identifying reliable biomarkers for predicting this transformation is crucial for early intervention.
Purpose Of The Study
- To systematically review and meta-analyze existing evidence on the role of EGFR upregulation in predicting OPMD malignant transformation risk.
- To quantitatively and qualitatively appraise the association between EGFR and OPMD progression.
Main Methods
- Comprehensive literature search across major databases (Web of Science, Embase, PubMed, Scopus).
- Inclusion of longitudinal primary studies (prospective and retrospective).
- Quality assessment using the QUIPS tool, followed by meta-analysis and sensitivity analyses.
Main Results
- Eight studies (nine analytical units) involving 653 patients were included.
- EGFR upregulation showed a significant association with increased OPMD malignant transformation risk (RR = 2.17).
- Subgroup analyses confirmed associations for EGFR protein overexpression, gene amplification, and specific cutoff points (>10% nuclear staining).
Conclusions
- EGFR overexpression, particularly via immunohistochemistry, serves as a valuable risk marker for OPMD malignant transformation.
- This supports the potential clinical utility of EGFR assessment in managing OPMD patients.
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