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Related Concept Videos

Atomic Emission Spectroscopy: Overview01:20

Atomic Emission Spectroscopy: Overview

Atomic emission spectroscopy (AES) is an analytical technique used to determine the elemental composition of a sample by analyzing the light emitted from excited atoms. In AES, atoms in a sample are excited to higher energy levels by thermal energy from high-temperature sources, such as plasma, arcs, or sparks. When these excited atoms return to lower energy states, they emit light at specific wavelengths characteristic of each element. The resulting atomic emission spectrum, which consists of...

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Quantifying Titanium Exposure in Lung Tissues: A Novel Laser-Induced Breakdown Spectroscopy Elemental Imaging-Based

Vincent Gardette1, Lucie Sancey2, Marine Leprince1

  • 1Université de Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière Villeurbanne 69100 France.

Small Science
|April 11, 2025
PubMed
Summary

This study introduces laser-induced breakdown spectroscopy (LIBS) to quantify titanium in lung tissue. This novel method aids in assessing environmental and occupational exposures linked to pulmonary diseases.

Keywords:
elemental quantificationenvironmental and occupational hazardslaser‐induced breakdown spectroscopylung tissuestitanium exposure

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Area of Science:

  • Toxicology
  • Respiratory Medicine
  • Analytical Chemistry

Background:

  • Occupational and environmental exposures, especially urban air pollution, are linked to pulmonary diseases.
  • Current diagnostic methods for lung diseases are established, but tools for assessing elemental contamination in lung tissue are underutilized.
  • Titanium (Ti) is a relevant element in occupational and environmental exposure studies.

Purpose of the Study:

  • To introduce and validate a novel laser-induced breakdown spectroscopy (LIBS) framework for in situ quantification of elemental titanium (Ti) in lung tissues.
  • To expand the utility of LIBS for volumetric organ analysis.
  • To provide a new diagnostic tool for assessing environmental or occupational exposure levels.

Main Methods:

  • Development of a novel LIBS framework for elemental quantification in biological tissues.
  • Validation using animal models exposed to titanium dioxide (TiO2) P25 nanoparticles.
  • Comparative analysis with established techniques like inductively coupled plasma mass spectrometry (ICP-MS).
  • Application to paraffin-embedded human lung specimens.

Main Results:

  • The developed LIBS method accurately quantifies elemental titanium in lung tissues.
  • A novel quantitative metric demonstrated a robust correlation with elemental concentrations.
  • The methodology was successfully applied to human lung specimens, showing LIBS's potential for volumetric analysis.
  • Validation confirmed the reliability of the LIBS approach against ICP-MS.

Conclusions:

  • The validated LIBS framework offers a promising tool for in situ elemental analysis in lung tissue.
  • This methodology can significantly contribute to assessing exposure to environmental and occupational hazards.
  • The study advances the fields of toxicology and respiratory medicine by providing a novel analytical approach.