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Updated: May 14, 2025

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Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: A Case Report and Clinical Insights
Audrey Grigore1, Lynne J Goebel2
1Internal Medicine, Joan C. Edwards School of Medicine at Marshall University, Huntington, USA.
Abstract:
Primary care providers are often the first contact for patients with neurodegenerative illnesses, however, they may not be aware of the relationship of certain diseases that may have an impact on their patients' longevity. This case report reminds clinicians of the association between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Physicians should be aware of the association, because FTD commonly occurs first and may prepare clinicians to be alert to the signs of ALS in these patients, leading to earlier detection of ALS and the prescription of disease-modifying medication that may extend the lifespan of people with these diseases. We describe the case of a 61-year-old female patient initially presenting with cognitive decline most likely due to FTD who subsequently developed ALS.
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