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Epigenetically Reprogrammed Nanovesicles as Inverse Vaccines for Antigen-Specific Immune Tolerance in Autoimmune

Yue Xi1, Huifeng Ma1,2, Xue Liu2

  • 1State Key Laboratory of Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.

Nano Letters
|April 11, 2025
PubMed
Summary

This study introduces an inverse vaccine (mDCNVreg) that uses epigenetic reprogramming to create antigen-specific immune tolerance for autoimmune diseases. This novel platform shows promise for durable, personalized therapies by inducing T cell anergy.

Keywords:
antigen deliveryantigen presentationcell membrane vesicleimmune toleranceimmunotherapy

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