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Published on: April 11, 2016
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Clinical Utility of Large Next-Generation Sequencing Panel Across Diverse Tumour Types: A Single-Center Retrospective
H P Chen1,2, Z Y Guo3, L M Zhang3
1Department of Pathology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, PR China.
Nigerian Journal of Clinical Practice
|April 11, 2025
Summary
Next-generation sequencing (NGS) identified actionable variants in most solid tumors, guiding personalized cancer therapy. Patients receiving targeted treatments showed significantly longer survival than those on traditional therapies.
Area of Science:
- Oncology
- Genomics
- Clinical Diagnostics
Background:
- Advanced technologies like next-generation sequencing (NGS) are vital for effective cancer patient management.
- Real-world clinical practice necessitates integrating sophisticated tools for tailored treatment strategies.
Purpose of the Study:
- To retrospectively evaluate the clinical utility of a large NGS panel in managing solid tumors.
- Assessing the impact of comprehensive genomic profiling in a clinical setting.
Main Methods:
- A comprehensive NGS panel was employed to analyze 431 solid tumor specimens from 416 patients.
- Detection of diagnostic, prognostic, and therapeutic biomarkers using a commercial NGS platform.
Main Results:
- Actionable variants were detected in 89.1% of specimens, with TP53, EGFR, KRAS, PIK3CA, and RB1 being frequently altered.
- Therapeutically targetable variants were found in 55.7% of cases, with 25.3% having available targeted therapies for their specific disease.
- Patients on targeted therapy/immune checkpoint inhibitors exhibited significantly longer survival compared to chemotherapy/radiotherapy recipients (P = 0.001).
Conclusions:
- Comprehensive genomic profiling demonstrates significant clinical utility in routine solid tumor testing.
- NGS facilitates personalized treatment decisions, improving patient outcomes in clinical practice.
