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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Related Experiment Video

Updated: May 14, 2025

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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BDNF Signaling and Pain Modulation.

Mariacristina Mazzitelli1, Takaki Kiritoshi1, Peyton Presto1

  • 1Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Cells
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) modulates nervous system functions and is implicated in pain. This review explores BDNF

Keywords:
BDNFTrkBneuroimmune signalingneuroplasticitypain

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Pain Research

Background:

  • Brain-derived neurotrophic factor (BDNF) is a key neuromodulator influencing neuronal functions.
  • BDNF signaling, primarily via tropomyosin receptor kinase B (TrkB), impacts neuronal growth, survival, neurotransmission, and synaptic plasticity.
  • BDNF is implicated in neuropsychiatric disorders and pain states.

Purpose of the Study:

  • To review the critical role of BDNF in the pain system.
  • To describe contrasting pro- and anti-nociceptive effects of BDNF.
  • To identify knowledge gaps in BDNF signaling in pain.

Main Methods:

  • Literature review summarizing existing evidence on BDNF in pain.
  • Discussion of cellular sources, neuroimmune signaling, and regional effects of BDNF.
  • Analysis of factors influencing BDNF's bidirectional effects in pain modulation.

Main Results:

  • BDNF plays a critical, yet complex, role in pain modulation with both pro- and anti-nociceptive effects.
  • Cellular sources, neuroimmune interactions, and regional expression influence BDNF's impact on pain.
  • Endogenous levels, signaling pathways, and administration routes contribute to BDNF's dual role.

Conclusions:

  • BDNF signaling exhibits bidirectional effects in pain plasticity and modulation.
  • Further research is needed to address sex- and pathway-specific differences in BDNF's role in pain.
  • Understanding these complexities is crucial for developing targeted pain therapies.