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Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation
Naila Arif Cheema1, Annalisa Castagna1, Francesca Ambrosani1
1Department of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, Italy.
Cells
|April 11, 2025
Summary
Extracellular vesicles (EVs) are key in asthma, reflecting molecular differences between type 2 (T2)-high and T2-low asthma. This review highlights EVs as potential biomarkers and therapeutic targets for distinct asthma endotypes.
Area of Science:
- Immunology
- Cell Biology
- Respiratory Medicine
Background:
- Asthma is a complex airway inflammatory disease with identified T2-high and T2-low endotypes.
- Extracellular vesicles (EVs), including exosomes, are crucial for intercellular communication and signaling.
- EVs from various airway cells are implicated in asthma pathogenesis.
Purpose of the Study:
- To review the role of EVs in understanding asthma endotypes.
- To explore EVs as molecular signatures for T2-high and T2-low asthma.
- To identify novel therapeutic targets based on EV functions.
Main Methods:
- Literature review of experimental evidence on EVs in asthma.
- Analysis of studies investigating EV composition and function in different asthma endotypes.
- Synthesis of current knowledge on EV-mediated intercellular communication in asthma.
Main Results:
- EVs secreted by diverse cell types (eosinophils, mast cells, etc.) modulate asthma.
- EVs can reflect the distinct molecular profiles of T2-high and T2-low asthma.
- EVs offer insights into disease mechanisms and potential therapeutic strategies.
Conclusions:
- EVs play a significant role in asthma pathobiology and endotype differentiation.
- Profiling EVs may aid in diagnosing and classifying asthma subtypes.
- Targeting EVs presents a promising avenue for novel asthma therapies.
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