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Updated: May 14, 2025

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The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration

Dolma Choezom1,2, Jan-Moritz Plum1,2, Pradhipa Karuna M1,2

  • 1Department of Hematology and Oncology, University Medical Center Goettingen, 37075 Goettingen, Germany.

Cells
|April 11, 2025
PubMed
Summary

Neutral sphingomyelinases (nSMases) impact prostate cancer progression by altering extracellular vesicle (EV) composition. Inhibiting nSMase 2 changes EV proteins, affecting cancer cell migration and offering new therapeutic targets.

Keywords:
SMPD2SMPD3cell migrationextracellular matrixneutral sphingomyelinases

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