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Latest Update on lncRNA in Epithelial Ovarian Cancer-A Scoping Review

Katarzyna Kwas1, Maria Szubert1, Jacek Radosław Wilczyński1

  • 1Department of Surgical and Oncologic Gynaecology, 1st Department of Gynaecology and Obstetrics, Medical University of Lodz, 90-136 Łódź, Poland.

Cells
|April 11, 2025
PubMed

Insights

Long noncoding RNAs (lncRNAs) are key regulators of gene expression implicated in cancer. This review explores their crucial, yet understudied, roles in epithelial ovarian cancer (EOC) progression and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) regulate gene expression and are involved in cancer development.
  • Epithelial ovarian cancer (EOC) has a complex pathogenesis and remains a clinical challenge.
  • The specific roles of lncRNAs in EOC are not fully understood.

Purpose of the Study:

  • To provide an updated overview of lncRNAs in epithelial ovarian cancer (EOC).
  • To highlight the potential of lncRNAs as biomarkers and therapeutic targets in EOC.
  • To identify knowledge gaps and suggest future research directions.

Main Methods:

  • Literature review of current research on lncRNAs and EOC.
  • Analysis of the involvement of specific lncRNAs (e.g., XIST, H19, NEAT1, MALAT1) in EOC.
  • Discussion of mechanisms by which lncRNAs influence EOC pathogenesis and chemoresistance.

Main Results:

  • lncRNAs are implicated in EOC progression, metastasis, and chemoresistance.
  • Specific lncRNAs modulate gene expression and signaling pathways affecting cell proliferation and invasion.
  • lncRNAs show promise as potential biomarkers and therapeutic targets for EOC.

Conclusions:

  • lncRNAs play significant roles in epithelial ovarian cancer (EOC) pathogenesis.
  • Further research is needed to fully elucidate the mechanisms of lncRNAs in EOC.
  • lncRNAs represent a promising avenue for novel EOC diagnostics and therapeutics.
Keywords:
epithelial ovarian cancerlong noncoding RNAmolecular pathogenesis

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