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EXO1 as a potential biomarker for prognosis, immune infiltration, and immunotherapy in pan-cancer analysis

  • 0Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, 530021, China.
Functional & Integrative Genomics +

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April 11, 2025

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April 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The exonuclease EXO1 is overexpressed in many cancers and linked to poor prognosis. Its role in DNA repair and immune response offers potential for targeted cancer therapies and personalized medicine.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Human EXO1 is a 5'→3' exonuclease crucial for DNA repair, cell cycle checkpoints, and replication fork maintenance.
  • Previous research indicated EXO1's importance in liver and breast cancers, but a comprehensive analysis across diverse cancers was lacking.
  • The precise role of EXO1 in cancer prognosis and immune response remained unclear.

Purpose Of The Study

  • To systematically investigate the associations between EXO1 expression, immune infiltration, and prognostic value across various cancer types.
  • To elucidate the underlying mechanisms of EXO1's action in cancer development and progression.
  • To explore EXO1's potential as a biomarker and therapeutic target in precision medicine.

Main Methods

  • Utilized multiple databases for a comprehensive analysis of EXO1 across diverse cancers.
  • Examined EXO1 expression, clinical survival correlations, immune checkpoints, and genomic profiles.
  • Investigated genetic mutations, RNA modifications, immunomodulators, and immunotherapy responses related to EXO1.

Main Results

  • EXO1 is significantly overexpressed in most tumors compared to normal tissues, correlating with poor prognosis in certain cancers.
  • EXO1 expression levels showed associations with tumor immunity, genomic stability, and immunomodulators.
  • Differential drug responses based on EXO1 levels were observed in Skin Cutaneous Melanoma (SKCM), indicating potential for personalized treatment.

Conclusions

  • EXO1 plays a multifaceted role in cancer initiation, progression, prognosis, and immune regulation.
  • EXO1's involvement in DNA repair and cell cycle pathways highlights its significance in cancer biology.
  • EXO1 presents a promising biomarker and therapeutic target for personalized cancer therapy and precision medicine.

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