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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

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Identification of the disulfidptosis-related key gene CD2AP as a potential biomarker and new therapeutic target for

Zhiwu Lin¹, Jing Lv², Chuanqiang Dai²

¹Department of Thoracic Surgery, Ziyang Central Hospital, Ziyang, 641300, China.

Discover Oncology

|April 11, 2025

Summary

CD2AP is overexpressed in lung adenocarcinoma (LUAD), correlating with poor prognosis and influencing immune escape and drug resistance. This suggests CD2AP as a potential biomarker and therapeutic target for LUAD treatment.

Keywords:

CD2AP Disulfidptosis Drug sensitivity LUAD Multi-omics Programmed cell death Therapeutic target

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Area of Science:

Oncology
Molecular Biology
Cell Death Mechanisms

Background:

Lung Adenocarcinoma (LUAD) presents a poor prognosis despite therapeutic advancements.
Disulfidptosis, a novel cell death pathway, and its regulators like CD2AP (CD2-associated protein) are implicated in tumor progression.

Purpose of the Study:

To investigate the role of CD2AP in LUAD.
To evaluate CD2AP as a potential biomarker for prognosis and therapeutic target in LUAD.

Main Methods:

Multi-omics analysis including transcriptomics and spatial transcriptomics on LUAD datasets (TCGA, GEO).
Kaplan-Meier survival analysis, enrichment analysis, and immune infiltration assays.
Assessment of CD2AP association with tumor microenvironment and drug sensitivity.

Main Results:

CD2AP is significantly overexpressed in LUAD, associated with poorer overall and progression-free survival.
High CD2AP expression correlates with cell adhesion, PI3K-Akt signaling, immune escape, and altered tumor immune microenvironment.
CD2AP expression predicts sensitivity to certain chemotherapeutics and resistance to targeted therapies.

Conclusions:

CD2AP plays a critical role in LUAD progression, immune modulation, and drug response.
CD2AP serves as a potential prognostic biomarker and therapeutic target for LUAD, particularly for immunotherapy and predicting drug response.