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Poster Session: Deviation mapping for foveal cone mosaic topography
Jenna Grieshop1, Emma Warr1, Ashleigh Walesa1
1Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI USA.
Journal of Vision
|April 11, 2025
Summary
This study introduces a new deviation mapping tool for adaptive optics scanning light ophthalmoscopy (AOSLO) to analyze the foveal cone mosaic. The tool helps assess retinal health by comparing individual scans to normative data, aiding in the diagnosis of retinal pathologies.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Cone Mosaic Analysis
Background:
- Deviation mapping is a standard technique in retinal imaging.
- A need exists for an adaptive optics scanning light ophthalmoscopy (AOSLO)-specific tool for foveal cone mosaic analysis.
Purpose of the Study:
- To develop and validate an AOSLO-specific deviation mapping tool for assessing the foveal cone mosaic.
- To compare cone density and nearest neighbor distance (NND) metrics in normative and pathological retinal regions.
Main Methods:
- Compiled AOSLO data from two independent laboratories.
- Identified foveal cones in 87 normative and 5 pathological regions of interest (ROIs).
- Generated density and NND maps, aligned them using the cone density centroid (CDC), and created average and standard deviation (SD) normative maps for comparison.
Main Results:
- Established normative average (SD) density of 1.79E+5 (2.55E+4) cones/mm^2 and NND of 2.08 (0.16) µm at the CDC.
- Pathological ROIs showed comparable deviation in density and NND to normative data, with some exceptions indicating mosaic irregularity or cone loss.
- Deviation mapping successfully identified deviations in individual foveal ROIs.
Conclusions:
- AOSLO-based deviation mapping is effective for assessing the normality of individual foveal cone mosaics.
- Comparing deviation maps of density and NND offers insights into the characteristics of the cone mosaic in retinal diseases.
- This tool can aid in the diagnosis and understanding of various retinal pathologies.
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