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Updated: May 8, 2025
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Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
Published on: September 29, 2014
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Neddylation and MASLD: From Pathophysiology to Therapy
Wenjun Lin1,2,3,4, Wenfang Zheng1,2,3, Nuo Dai5
1Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China.
Summary
Neddylation, a key protein modification, is increasingly linked to metabolic dysfunction-associated steatotic liver disease (MASLD). This review explores neddylation
Area of Science:
- Biochemistry
- Hepatology
- Molecular Biology
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD), previously NAFLD, involves hepatic metabolic dysregulation.
- Neddylation, the attachment of Nedd8 to proteins, influences protein function and is implicated in MASLD.
- The interplay between neddylation and MASLD pathogenesis is an emerging research focus.
Purpose of the Study:
- To review recent advancements on neddylation's role in MASLD.
- To summarize evidence linking neddylation to MASLD onset and progression.
- To explore therapeutic strategies targeting neddylation for MASLD.
Main Methods:
- Literature review of current research on neddylation and MASLD.
- Analysis of established and potential roles of neddylation in liver disease.
- Synthesis of biological mechanisms and therapeutic implications.
Main Results:
- Neddylation is involved in critical pathological stages of MASLD.
- Evidence supports neddylation's contribution to MASLD initiation and advancement.
- Neddylation pathways offer potential therapeutic targets for MASLD treatment.
Conclusions:
- Neddylation plays a significant role in the pathogenesis of MASLD.
- Targeting neddylation pathways may offer novel therapeutic avenues for MASLD.
- Further research is warranted to fully elucidate neddylation's impact and therapeutic potential in MASLD.
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