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Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy
Futing Wang1, Suping Deng2, Changxiao Song1
1Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
ACS Nano
|April 11, 2025
Summary
This study introduces a smart hydrogel that detects wound infection markers and uses light to kill bacteria and release drugs. This dual-action approach enables real-time wound monitoring and accelerated healing.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Wound infection monitoring and treatment remain critical challenges in healthcare.
- Developing multifunctional materials for simultaneous diagnosis and therapy is highly desirable.
- Current strategies often lack real-time feedback and targeted therapeutic delivery.
Purpose of the Study:
- To design a multifunctional palladium-gold (Pd@Au) nanoframe hydrogel for detecting uric acid (UA) as a wound infection biomarker.
- To develop a chemo-photothermal strategy for enhanced wound healing using the Pd@Au nanoframe hydrogel.
- To create a closed-loop system for in situ wound monitoring and therapeutic intervention.
Main Methods:
- Synthesis of multifunctional Pd@Au nanoframe hydrogels.
- Evaluation of peroxidase-like activity in acidic conditions for antibacterial ROS generation.
- Assessment of photothermal conversion under near-infrared (NIR) laser irradiation.
- Drug delivery studies of mupirocin (M) release triggered by NIR.
- In vitro antimicrobial efficacy testing against Escherichia coli.
- In vivo wound healing experiments in rabbits with UA sensing and chemo-photothermal therapy.
Main Results:
- Pd@Au nanoframe hydrogels exhibited high peroxidase-like activity, generating reactive oxygen species (ROS) for antibacterial action.
- NIR laser irradiation induced efficient photothermal conversion, increasing temperature significantly.
- Mupirocin-loaded hydrogels demonstrated controlled release (>90%) upon NIR irradiation.
- In vitro studies showed 98% killing of Escherichia coli within 10 minutes with NIR treatment.
- In vivo rabbit wound models showed accelerated healing in 4 days using the UA sensing and chemo-photothermal therapy patch.
Conclusions:
- The designed Pd@Au nanoframe hydrogel acts as a multifunctional platform for wound management.
- The chemo-photothermal strategy effectively combines diagnostics (UA sensing) with therapy (antibacterial ROS and drug release).
- This closed-loop system offers a promising approach for real-time wound monitoring and accelerated, synergistic wound healing.
Keywords:
chemo-photothermal strategyin situ monitoringmultifunctional Pd@Au nanoframe hydrogelsnear-infraredperoxidase-like activity
