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Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy.

Futing Wang1, Suping Deng2, Changxiao Song1

  • 1Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

ACS Nano
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a smart hydrogel that detects wound infection markers and uses light to kill bacteria and release drugs. This dual-action approach enables real-time wound monitoring and accelerated healing.

Keywords:
chemo-photothermal strategyin situ monitoringmultifunctional Pd@Au nanoframe hydrogelsnear-infraredperoxidase-like activity

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing Research

Background:

  • Wound infection monitoring and treatment remain critical challenges in healthcare.
  • Developing multifunctional materials for simultaneous diagnosis and therapy is highly desirable.
  • Current strategies often lack real-time feedback and targeted therapeutic delivery.

Purpose of the Study:

  • To design a multifunctional palladium-gold (Pd@Au) nanoframe hydrogel for detecting uric acid (UA) as a wound infection biomarker.
  • To develop a chemo-photothermal strategy for enhanced wound healing using the Pd@Au nanoframe hydrogel.
  • To create a closed-loop system for in situ wound monitoring and therapeutic intervention.

Main Methods:

  • Synthesis of multifunctional Pd@Au nanoframe hydrogels.
  • Evaluation of peroxidase-like activity in acidic conditions for antibacterial ROS generation.
  • Assessment of photothermal conversion under near-infrared (NIR) laser irradiation.
  • Drug delivery studies of mupirocin (M) release triggered by NIR.
  • In vitro antimicrobial efficacy testing against Escherichia coli.
  • In vivo wound healing experiments in rabbits with UA sensing and chemo-photothermal therapy.

Main Results:

  • Pd@Au nanoframe hydrogels exhibited high peroxidase-like activity, generating reactive oxygen species (ROS) for antibacterial action.
  • NIR laser irradiation induced efficient photothermal conversion, increasing temperature significantly.
  • Mupirocin-loaded hydrogels demonstrated controlled release (>90%) upon NIR irradiation.
  • In vitro studies showed 98% killing of Escherichia coli within 10 minutes with NIR treatment.
  • In vivo rabbit wound models showed accelerated healing in 4 days using the UA sensing and chemo-photothermal therapy patch.

Conclusions:

  • The designed Pd@Au nanoframe hydrogel acts as a multifunctional platform for wound management.
  • The chemo-photothermal strategy effectively combines diagnostics (UA sensing) with therapy (antibacterial ROS and drug release).
  • This closed-loop system offers a promising approach for real-time wound monitoring and accelerated, synergistic wound healing.